Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: Behavioral and anatomical assessment
Identifieur interne : 000C90 ( Main/Corpus ); précédent : 000C89; suivant : 000C91Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: Behavioral and anatomical assessment
Auteurs : Ray L. Watts ; Allen S. Mandir ; Roy A. E. BakaySource :
- Cell Transplantation [ 0963-6897 ] ; 1994.
Abstract
To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkin-sonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal-cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.
Url:
DOI: 10.1016/0963-6897(95)92155-R
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Watts</name><affiliation><mods:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</mods:affiliation></affiliation></author><author><name sortKey="Mandir, Allen S" sort="Mandir, Allen S" uniqKey="Mandir A" first="Allen S." last="Mandir">Allen S. Mandir</name><affiliation><mods:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</mods:affiliation></affiliation></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><affiliation><mods:affiliation>Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322 USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell Transplantation</title><title level="j" type="abbrev">CTR</title><idno type="ISSN">0963-6897</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="27">27</biblScope><biblScope unit="page" to="38">38</biblScope></imprint><idno type="ISSN">0963-6897</idno></series><idno type="istex">94A16210BD8C5EB419628FB0D32BBDDB1DDC8D4B</idno><idno type="DOI">10.1016/0963-6897(95)92155-R</idno><idno type="PII">0963-6897(95)92155-R</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0963-6897</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkin-sonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal-cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Ray L. Watts</name><affiliations><json:string>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</json:string></affiliations></json:item><json:item><name>Allen S. Mandir</name><affiliations><json:string>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</json:string></affiliations></json:item><json:item><name>Roy A.E. Bakay</name><affiliations><json:string>Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322 USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Cograft</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Adrenal medulla</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sural nerve</value></json:item></subject><language><json:string>eng</json:string></language><abstract>To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkin-sonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal-cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. 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Watts, MD, Department of Neurology, Emory University School of Medicine, 6000 WMB, P.O. Drawer V, Atlanta, GA 30322 USA.</p></note><affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</affiliation></author><author><persName><forename type="first">Allen S.</forename><surname>Mandir</surname></persName><affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</affiliation></author><author><persName><forename type="first">Roy A.E.</forename><surname>Bakay</surname></persName><affiliation>Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322 USA</affiliation></author></analytic><monogr><title level="j">Cell Transplantation</title><title level="j" type="abbrev">CTR</title><idno type="pISSN">0963-6897</idno><idno type="PII">S0963-6897(00)X0012-7</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="27">27</biblScope><biblScope unit="page" to="38">38</biblScope></imprint></monogr><idno type="istex">94A16210BD8C5EB419628FB0D32BBDDB1DDC8D4B</idno><idno type="DOI">10.1016/0963-6897(95)92155-R</idno><idno type="PII">0963-6897(95)92155-R</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1995</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkin-sonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal-cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Cograft</term></item><item><term>Parkinsonism</term></item><item><term>Adrenal medulla</term></item><item><term>Sural nerve</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-09-06">Registration</change><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>CTR</jid><aid>9592155R</aid><ce:pii>0963-6897(95)92155-R</ce:pii><ce:doi>10.1016/0963-6897(95)92155-R</ce:doi><ce:copyright type="unknown" year="1995"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Original contribution</ce:textfn></ce:dochead><ce:title>Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: Behavioral and anatomical assessment</ce:title><ce:author-group><ce:author><ce:given-name>Ray L.</ce:given-name><ce:surname>Watts</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Allen S.</ce:given-name><ce:surname>Mandir</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Roy A.E.</ce:given-name><ce:surname>Bakay</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322 USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Yerkes Regional Primate Research Center, Atlanta, Georgia 30322 USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Correspondence should be addressed to Ray L. Watts, MD, Department of Neurology, Emory University School of Medicine, 6000 WMB, P.O. Drawer V, Atlanta, GA 30322 USA.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="6" month="9" year="1994"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkin-sonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal-cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Cograft</ce:text></ce:keyword><ce:keyword><ce:text>Parkinsonism</ce:text></ce:keyword><ce:keyword><ce:text>Adrenal medulla</ce:text></ce:keyword><ce:keyword><ce:text>Sural nerve</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: Behavioral and anatomical assessment</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: Behavioral and anatomical assessment</title></titleInfo><name type="personal"><namePart type="given">Ray L.</namePart><namePart type="family">Watts</namePart><affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</affiliation><description>Correspondence should be addressed to Ray L. Watts, MD, Department of Neurology, Emory University School of Medicine, 6000 WMB, P.O. Drawer V, Atlanta, GA 30322 USA.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Allen S.</namePart><namePart type="family">Mandir</namePart><affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roy A.E.</namePart><namePart type="family">Bakay</namePart><affiliation>Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><dateValid encoding="w3cdtf">1994-09-06</dateValid><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkin-sonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal-cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.</abstract><note type="content">Section title: Original contribution</note><subject><genre>Keywords</genre><topic>Cograft</topic><topic>Parkinsonism</topic><topic>Adrenal medulla</topic><topic>Sural nerve</topic></subject><relatedItem type="host"><titleInfo><title>Cell Transplantation</title></titleInfo><titleInfo type="abbreviated"><title>CTR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199501</dateIssued></originInfo><identifier type="ISSN">0963-6897</identifier><identifier type="PII">S0963-6897(00)X0012-7</identifier><part><date>199501</date><detail type="issue"><title>Neural Transplantation into the CNS</title></detail><detail type="volume"><number>4</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>154</end></extent><extent unit="pages"><start>27</start><end>38</end></extent></part></relatedItem><identifier type="istex">94A16210BD8C5EB419628FB0D32BBDDB1DDC8D4B</identifier><identifier type="DOI">10.1016/0963-6897(95)92155-R</identifier><identifier type="PII">0963-6897(95)92155-R</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/94A16210BD8C5EB419628FB0D32BBDDB1DDC8D4B/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">MEDICINE, RESEARCH & EXPERIMENTAL</classCode><classCode scheme="WOS">TRANSPLANTATION</classCode><classCode scheme="WOS">CELL & TISSUE ENGINEERING</classCode><classCode scheme="WOS">CELL BIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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